Journal article
Combating mutations in genetic disease and drug resistance: understanding molecular mechanisms to guide drug design
ATS Albanaz, CHM Rodrigues, DEV Pires, DB Ascher
Expert Opinion on Drug Discovery | TAYLOR & FRANCIS LTD | Published : 2017
Abstract
Introduction: Mutations introduce diversity into genomes, leading to selective changes and driving evolution. These changes have contributed to the emergence of many of the current major health concerns of the 21st century, from the development of genetic diseases and cancers to the rise and spread of drug resistance. The experimental systematic testing of all mutations in a system of interest is impractical and not cost-effective, which has created interest in the development of computational tools to understand the molecular consequences of mutations to aid and guide rational experimentation. Areas covered: Here, the authors discuss the recent development of computational methods to unders..
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Grants
Awarded by University of Melbourne
Funding Acknowledgements
This work was funded by the Jack Brockhoff Foundation (JBF 4186, 2016) and a Newton Fund RCUK-CONFAP Grant awarded by The Medical Research Council (MRC) and Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG) (MR/M026302/1). This research was supported by the Victorian Life Sciences Computation Initiative (VLSCI), an initiative of the Victorian Government, Australia, on its Facility hosted at the University of Melbourne (UOM0017). DEV Pires receives support from the Rene Rachou Research Center (CPqRR/FIOCRUZ Minas), Brazil. DB Ascher is supported by a C. J. Martin Research Fellowship from the National Health and Medical Research Council of Australia (APP1072476), and the Department of Biochemistry, University of Melbourne.